In recent news a major breakthrough has occurred with how we can study Alzheimer’s, or at least one I would call major.  They have discovered how to genetically engineer Alzheimer’s in rats in a way that correctly emulate Alzheimer’s in humans.  Mice have been used for study for some time, and even in this same way, however rat’s are marginally more intelligent which makes a big difference.  Since Alzheimer’s directly relates to a decline in memory and other brain function, more intelligence to start out with equals more research potential.  Also, since the behavior in rats is more predictable, their decline in learning and action can more easily be observed.

Another advantage this new test subject holds to its predecessor is how the disease comes on.  In humans the disease forms in stages that have been clearly observed, however in mice it was more of a yes/no type scenario, leaving little room to study how or why exactly it forms.  Rat’s however, mimic humans in the onset of the disease, allowing researchers a much broader field of analysis and can lead to breakthroughs in the early predicting of the onset of the disease.  This thus could also lead to breakthroughs in preventative measures.

Source: http://www.medicalnewstoday.com/articles/184204.php

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It is estimated that taking care of terminal patients costs about 25%of our current budget, and the question was raised as to whether or not this is worth it.  This question takes some careful deliberation before actually forming an opinion.

Firstly, what exactly defines terminal care?  Is it when a person is on their deathbed?  When a person has aides?  When a person goes to the hospital?  I mean after all, we are all putting off the seemingly inevitable every time we get treatment.  From this perspective, when can we draw the line on when it’s no longer worth it?  When can we say, well now it’s just time for you to go peacefully?

Well honestly, I believe the answer is in that question.  When is it time to go… Peacefully.  One of the hardest things a person has to do in their life… is face death.  We do it in different ways, through different experiences.  We all wonder about it frequently, and we create many many theories on what life and death is.  We theorize on what happens afterward, and some feel  we just decompose, and there is no more.  My personal beliefs and theories are not what’s important here, so I won’t get into them… But no matter what, we all have to face the idea of death at some point.  Some just do it more than others by thinking philosophically.

The trick at this point, is becoming not afraid, even ready… to the best of our abilities.  Ultimately death is the BIG UNKNOWN.  We don’t know what it is, what it means, or what happens when we die.  We can claim we know, but we don’t.  At best we have theories and beliefs, but no true knowledge.  We can find solace and these theories and beliefs, but when the time comes, it is still ultimately a big unknown.

Facing the unknown is a dreadfully scary process… Especially when the amount of unknowing is 100%.  Usually we have at least something to go by, or people to help, like in school.  We know that we live on through everyone we’ve effected in life, after all, we come apart of who they are.. But still, what happens to “us”.

Hehe, ok, back to topic before I get into my own theories J.  The point is, terminal healthcare has a great deal of importance as it helps a person prepare to take that final leap.  It helps relatives face the idea of death as well.  It helps everyone to continue, as sad as a process as it may be.  So yes, to an extent it is VERY important.

However, at the same time, limits need to be placed.  I vote a price limit be set, which essentially places a time limit on the situation.  Something reasonable of course, though I am not educated enough to give a number.  I would love to hear other peoples thoughts and comments on this, so please post if interested!!  Though I would appreciate keeping theories on life and death out of it.  That’s for a philosophical forum… which I would also love to talk to any of you about…

Later, when the nurses were going through his meager possessions, they found this poem. Its quality and content so impressed the
staff that copies were made and distributed to every nurse in the hospital. One nurse took her copy to Missouri. The old man’s sole bequest to posterity has since appeared in the Christmas edition of the News Magazine of the St. Louis Association for Mental Health. A slide presentation has also been made based on his simple, but eloquent, poem.

And this little old man, with nothing left to give to the world,
is now the author of this ‘anonymous’ poem winging across the Internet.

Crabby Old Man

What do you see nurses? . . . .. . What do you see?
What are you thinking . . . . . When you’re looking at me?
A crabby old man .. . . . . Not very wise,
Uncertain of habit . . . . . With faraway eyes?

Who dribbles his food . . . . . And makes no reply.
When you say in a loud voice . . . . . ‘I do wish you’d try!’
Who seems not to notice . . . . . The things that you do.
And forever is losing . . . . . A sock or shoe?

Who, resisting or not . . . . . Lets you do as you will,
With bathing and feeding . . . . . The long day to fill?
Is that what you’re thinking? . . . . . Is that what you see?
Then open your eyes, nurse . . . . . You’re not looking at me.

I’ll tell you who I am. . … . . . As I sit here so still,
As I do at your bidding, . . . . . As I eat at your will.
I’m a small child of Ten . . . . . With a father and mother,
Brothers and sisters . . . . . Who love one another.

A young boy of Sixteen . . . . With wings on his feet.
Dreaming that soon now . . . . . A lover he’ll meet.
A groom soon at Twenty . . . . . My heart gives a leap.
Remembering, the vows . . . . . That I promised to keep.

At Twenty-Five, now . . . . . I have young of my own.
Who need me to guide . . . . . And a secure happy home.
A man of Thirty . … . . . My young now grown fast,
Bound to each other . . . . . With ties that should last.

At Forty, my young sons . . . . . Have grown and are gone,
But my woman’s beside me . . . . . To see I don’t mourn.
At Fifty, once more, babies play ’round my knee,
Again, we know children . . . . . My loved one and me.

Dark days are upon me . . . . . My wife is now dead.
I look at the future . . . . . Shudder with dread.
For my young are all rearing . . . . . Young of their own.
And I think of the years . . . . . And the love that I’ve known.

I’m now an old man … . . . . And nature is cruel.
Tis jest to make old age . . . .. . Look like a fool.
The body, it crumbles . . . . . Grace and vigor, depart.
There is now a stone . .. . . Where I once had a heart.

But inside this old carcass . . . . . A young guy still dwells,
And now and again . . . . . My battered heart swells.
I remember the joys . . . . . I remember the pain.
And I’m loving and living . . . . . Life over again.

I think of the years, all too few . . . . . Gone too fast.
And accept the stark fact . . . . That nothing can last.
So open your eyes, people . . . . . Open and see.
Not a crabby old man . . . Look closer . . . See ME!!

Remember this poem when you next meet

An older person who you might brush aside

Without looking at the young soul within.

We will all, one day, be there, too!

Start early and stick with it. The Center on Aging’s Carl Eisdorfer says engaging in mental stimulation and complex cognitive activities such as multilingualism from a very young age tends to increase a persons cognitive reserve later, especially in women, but mental stimulation throughout a lifetime is equally important.

Exercise, exercise, exercise. A fair amount of research shows what’s good for your heart is good for your brain too. Exercise that improves circulation appears to promote the creation of hormones that enhance brain health.

Manage stress. Have a program in place for relieving pressure. When exercise isn’t enough to defuse stress, try daily deep-breathing or guided imagery exercises. Studies have shown that monkeys living under high stress conditions loose brain cells and that people who suffered traumatic experiences may have a smaller hippocampus, the part of the brain involved in memory. Stress also elevates cortisol, a hormone toxic to brain cells.

Use those brain cells. Brain fitness software can be good for staying sharp, as is any other mentally stimulating activity-particularly doing crossword puzzles, playing musical instruments and board games, and learning a new language. The idea is to push your brain to form new connections over time rather then perform routine tasks that don’t require much thought.

Eat right. Take a cue from a Mediterranean diet, which relies on plenty of fresh fruit and vegetables; small amounts of red meat; lots of fish, olive oil, and other monounsaturated oils: and some dairy and nuts.

Be happy. People living with stress tend to be in a bad mood or become depressed, and people with a history of depression are more likely to develop dementia.

Stay Socially active. People with big social networks appear to handle stress better then those living in relative isolation.

Brain Matters Research

4723 West Atlantic Avenue
Delray Beach, Florida 33445
Phone: 1-888-739-7974

Is it appropriate to include Alzheimer’s disease patients in non-AD clinical research?
Dr. Yaari, associate director of the Memory Disorders Clinic at Banner Alzheimer’s Institute, Phoenix, Ariz.

Investigation studies for novel compounds treating Alzheimer’s disease (AD) require participation of people with the condition.  Although some patients with early AD have capacity to provide their own informed consent, the majority of patients with AD have impaired decisional capacity requiring a surrogate to provide consent.  It is common practice in AD studies to obtain consent from a legally authorized representative, usually a close relative, and an asset from the patient.  Although imperfect, guidelines and processes have been developed to allow persons with diminished decision-making capacity due to AD to participate in clinical trials focused on treatments for AD.

Participation in clinical trials provides numerous benefits to AD patients and their families, and in addition to current practice guidelines for AD, should be routinely offered as standard care.  A clinical trial can provide a novel therapy for AD that may improve a patient’s condition, but these patients will suffer from co morbid medical conditions that often have a negative impact on cognitive functioning, quality of life of their caregiver.  Clinical trials for conditions such as hypertension, hypercholesterolemia, and diabetes, just to name a few, can certainly benefit from including AD patients by aiding enrollment and improving the generalizablity and safety of the treatment.  However, some compounds or procedures in clinical trials should exclude persons with AD if there is a significant risk of worsening the patient’s condition.

During the course of a study, patients receive close (and free) medical monitoring in addition to social, educational, and behavioral support and problem solving that is typically not otherwise available.  Most importantly, clinical trial participation provides not only hope, but an authentic sense of purpose that their efforts are a part of a larger picture in finding therapies that will help people in the future.

Given that therapeutic trials in AD have proven the feasibility of conducting a trial in this population in terms of medication adherence, reporting of adverse events, and obtaining metrics of the treatment’s effectiveness, then in general, there should be no reason to exclude persons with AD from non-AD treatment trials so long as the patient has a reliable care partner and study partner.

Brain-Matters-Research-Mark-Brody
Alzheimer’s Clinical Research in Florida

4723 West Atlantic Avenue
Delray Beach, Florida 33445
Phone: 1-888-739-7974